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Human trialsGrowth hormone hGH fragment 176-191

AOD-9604

A GH fragment that was properly tested for obesity in humans — and did not work.

Class
Human growth hormone C-terminal fragment
Molar mass
1,817 g/mol
Half-life
Short
Human PK
Published
Regulatory
Removed from Category 2 in Sept 2024 after nomination withdrawn; not permitted
Sport
Monitored

What it is claimed to help

These are the uses attached to AOD-9604 in research, clinical practice, or marketing. Listing a claim is not endorsing it — tap any of them to see every other compound carrying the same claim.

What the human evidence actually is

Grade: Human trials

Randomised controlled human trials exist. Not necessarily approved, and not necessarily positive.

This one has a real answer, and it is no. Metabolic Pharmaceuticals ran randomised placebo-controlled obesity trials, including a 12-week phase 2b in several hundred people. AOD-9604 failed to produce significant weight loss versus placebo and development for obesity was abandoned. It is still sold for fat loss.

How it is supposed to work

Corresponds to the lipolytic C-terminal region of hGH; intended to trigger fat breakdown without hGH's growth or glucose effects.

Safety

Well tolerated in trials — safety was never the issue. Efficacy was.

Storage and handling

Lyophilised peptide is generally stored at 2–8 °C, or below −20 °C for long-term storage. Reconstituted in bacteriostatic water (0.9% benzyl alcohol) a solution is typically treated as usable for about 28 days refrigerated, versus roughly 24 hours for plain sterile water, which has no preservative. Add the water slowly down the vial wall and swirl — never shake, which shears peptide chains and foams the solution.

The arithmetic is the dangerous part

Whatever number a protocol or a prescriber gave you, converting it into syringe units is where a misplaced decimal becomes a tenfold error. Our calculators do that conversion and nothing else — they never invent a dose.

Open the calculators

Sources

  1. Metabolic Pharmaceuticals phase 2b obesity trial results
  2. Stier H et al. AOD-9604 safety review, 2013
  3. FDA 503A bulks list Category 2 removal notice, September 2024

Verified against primary sources on 27 August 2026. Regulatory status in this field changes several times a year. See How We Rate Evidence.

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