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Quick reference

Weight-loss peptides, with the numbers and the evidence side by side.

Everything on this site claimed to move body weight — from FDA-approved GLP-1s down to compounds nobody has tested in a person. The protocol table is a supplier’s published reference. The grade beside each name is ours, and it is the part that matters.

Protocol reference

PeptideVialBAC waterDoseUnitsTimingFrequencyCycle
SemaglutideFat loss3 mg2 ml250 mcg17AMOnce weekly8 wk on / 8 off
TirzepatideFat loss10 mg2 ml0.5 mg10AM3× weeklyUntil goal
CagrilintideAppetite5 mg2 ml250 mcg10AM3× weeklyAs needed
TesamorelinFat loss10 mg2 ml1 mg20AM / PM5 on / 2 off8 wk on / 8 off
AOD-9604Fat loss5 mg2 ml300 mcg11AM5 on / 2 off8 wk on / 8 off
IpamorelinFat loss10 mg3 ml300 mcg9AM / PM5 on / 2 off8 wk on / 8 off
MOTS-cFat loss10 mg2 ml1 mg20AM5 on / 2 off8 wk on / 8 off
Ipamorelin / CJC-1295 no DACFat loss5/5 mg2 ml250/250 mcg10AM / PM5 on / 2 off8 wk on / 8 off
Tesamorelin / IpamorelinFat loss / muscle6/2 mg2 ml300/100 mcg10AM / PM5 on / 2 off8 wk on / 8 off
5-Amino-1MQFat loss / endurance10 mg2 ml2 mg20AM5 days/wk6–8 wk cycle
GLP-3Fat loss10 mg2 ml0.5 mg10AM3× weeklyUntil goal
Lepto3GRFat loss100 mcg1 ml25 mcg25AM / PMWeekly / biweeklyUntil goal
NAD+ / MOTS-c / 5-Amino-1MQFat loss blend100/10/102 ml500 mcg / 1 mg10AM5 on / 2 off8 wk on / 8 off
PEG-MGFMuscle / fat loss5 mg2.5 ml200 mcg10Post workout2–3 days/wk6–8 wk / 8 off
Follistatin (FLGR242)Muscle / fat loss5 mg1 ml2.5–5 mg0.5–1 mlAM, SubQ onlyEvery 2 weeks12–16 wk / 8 off
MicroFLGRFat loss / muscle1 mg1 ml0.5–1 mg0.5–1 mlSubQ fat onlyWeekly / biweekly12–16 wk / 6 off
Slim AssistFat loss / muscle2 mg1 ml1 mg0.5–1 mlSubQ fat onlyWeekly / biweeklyUp to 16 wk / 6 off

What the evidence says, compound by compound

15 compounds in the dictionary are claimed for weight, fat or obesity. Read the grade before the protocol.

LiraglutideFDA-approved

The first-generation daily GLP-1. Superseded on potency, but with long outcome data.

Claimed for: type 2 diabetes, obesity, weight loss, cardiovascular risk
OrforglipronFDA-approved

Not a peptide at all — and that is the point. The first oral small-molecule GLP-1, approved April 2026.

Claimed for: obesity, weight loss, type 2 diabetes, sleep apnea, knee osteoarthritis
SemaglutideFDA-approved

A prescription GLP-1 with a real FDA label and some of the largest outcome trials in medicine.

Claimed for: type 2 diabetes, obesity, weight loss, heart failure (HFpEF), cardiovascular risk
SermorelinFDA-approved

Was an approved diagnostic and paediatric GH agent. Withdrawn commercially, now compounded.

Claimed for: growth hormone, growth hormone deficiency, anti-aging, sleep quality, muscle gain
SetmelanotideFDA-approved

An approved melanocortin peptide — but only for specific genetic obesity syndromes.

Claimed for: genetic obesity, POMC deficiency, LEPR deficiency, Bardet-Biedl syndrome, hyperphagia
TesamorelinFDA-approved

The only GH-axis peptide with a real FDA approval — for one specific indication.

Claimed for: visceral fat, HIV lipodystrophy, fatty liver, NAFLD, belly fat
TirzepatideFDA-approved

An approved dual-receptor drug with the largest average weight loss of any approved agent.

Claimed for: type 2 diabetes, obesity, weight loss, sleep apnea, heart failure (HFpEF)
AOD-9604Human trials

A GH fragment that was properly tested for obesity in humans — and did not work.

Claimed for: fat loss, obesity, weight loss, cartilage repair, osteoarthritis
CagrilintideHuman trials

An amylin analogue built to pair with semaglutide rather than replace it.

Claimed for: obesity, weight loss, appetite suppression
MazdutideHuman trials

An oxyntomodulin-based dual agonist approved in China, unapproved in the US.

Claimed for: obesity, weight loss, type 2 diabetes
RetatrutideHuman trials

A triple agonist in late-stage trials with the largest phase 2 weight loss ever published.

Claimed for: obesity, weight loss, type 2 diabetes, fatty liver, MASH
SurvodutideHuman trials

A glucagon/GLP-1 dual agonist with unusually strong phase 2 liver data.

Claimed for: obesity, weight loss, fatty liver, MASH, liver fibrosis
CJC-1295Early human

A GHRH analogue that reliably raises GH in humans — with no outcome trials behind it.

Claimed for: growth hormone, muscle gain, fat loss, recovery, sleep quality
IpamorelinEarly human

The 'clean' GH secretagogue — selective, well characterised pharmacologically, unproven clinically.

Claimed for: growth hormone, muscle gain, fat loss, recovery, sleep quality
MOTS-cAnimal-only

A genuine mitochondrial-derived peptide with excellent mouse data and no human trials.

Claimed for: metabolic health, insulin resistance, obesity, exercise capacity, longevity

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