What it is claimed to help
These are the uses attached to DSIP in research, clinical practice, or marketing. Listing a claim is not endorsing it — tap any of them to see every other compound carrying the same claim.
What the human evidence actually is
Small, uncontrolled, foreign-registry or single-group human studies only.
Old, small and inconsistent. Human studies from the 1980s reported effects on sleep architecture in some subjects and not others, and some found no reliable hypnotic effect at all. Small studies in opioid and alcohol withdrawal reported symptom reduction. The FDA briefing and the advisory panel both concluded this was not enough: DSIP was the single rejection out of seven peptides reviewed.
How it is supposed to work
Isolated from rabbit cerebral venous blood during induced sleep. Its actual receptor and mechanism remain unidentified after four decades.
Safety
Short human exposures were tolerated. No modern safety data.
Storage and handling
Lyophilised peptide is generally stored at 2–8 °C, or below −20 °C for long-term storage. Reconstituted in bacteriostatic water (0.9% benzyl alcohol) a solution is typically treated as usable for about 28 days refrigerated, versus roughly 24 hours for plain sterile water, which has no preservative. Add the water slowly down the vial wall and swirl — never shake, which shears peptide chains and foams the solution.
Whatever number a protocol or a prescriber gave you, converting it into syringe units is where a misplaced decimal becomes a tenfold error. Our calculators do that conversion and nothing else — they never invent a dose.
Open the calculatorsSources
- FDA PCAC briefing document and vote, 24 July 2026
- Schneider-Helmert D et al. DSIP sleep studies, 1980s
Verified against primary sources on 27 August 2026. Regulatory status in this field changes several times a year. See How We Rate Evidence.