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FDA-approvedNeuro Pitocin, Syntocinon

Oxytocin

An approved obstetric drug with an enormous, largely unsupported social-behaviour literature.

Class
Nonapeptide hormone
Molar mass
1,007 g/mol
Half-life
~1-6 min (IV)
Human PK
Fully characterised
Regulatory
FDA-approved (obstetric use)
Sport
Not listed

What it is claimed to help

These are the uses attached to Oxytocin in research, clinical practice, or marketing. Listing a claim is not endorsing it — tap any of them to see every other compound carrying the same claim.

What the human evidence actually is

Grade: FDA-approved

Approved by the FDA with randomised human trial data behind the label.

Split. For labour induction and postpartum haemorrhage the evidence and approval are solid. For the social and psychiatric claims, intranasal oxytocin has been tested repeatedly — including a large NIH-funded randomised trial in autistic children that found no benefit — and replication has been poor across the field. High-dose obstetric use carries real risk.

How it is supposed to work

Oxytocin receptor agonist causing uterine contraction and milk ejection; central effects are much less well characterised, and intranasal brain penetration is disputed.

Safety

Boxed warning against elective labour induction. Water intoxication and hyponatraemia at high doses. Intranasal use in trials was generally well tolerated.

Storage and handling

Lyophilised peptide is generally stored at 2–8 °C, or below −20 °C for long-term storage. Reconstituted in bacteriostatic water (0.9% benzyl alcohol) a solution is typically treated as usable for about 28 days refrigerated, versus roughly 24 hours for plain sterile water, which has no preservative. Add the water slowly down the vial wall and swirl — never shake, which shears peptide chains and foams the solution.

The arithmetic is the dangerous part

Whatever number a protocol or a prescriber gave you, converting it into syringe units is where a misplaced decimal becomes a tenfold error. Our calculators do that conversion and nothing else — they never invent a dose.

Open the calculators

Sources

  1. FDA prescribing information, Pitocin
  2. Sikich L et al. Intranasal oxytocin in autism, NEJM 2021

Verified against primary sources on 27 August 2026. Regulatory status in this field changes several times a year. See How We Rate Evidence.

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