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FDA-approvedMetabolic Victoza, Saxenda

Liraglutide

The first-generation daily GLP-1. Superseded on potency, but with long outcome data.

Class
GLP-1 receptor agonist
Molar mass
3,751 g/mol
Half-life
~13 h
Human PK
Fully characterised
Regulatory
FDA-approved
Sport
Not prohibited

What it is claimed to help

These are the uses attached to Liraglutide in research, clinical practice, or marketing. Listing a claim is not endorsing it — tap any of them to see every other compound carrying the same claim.

What the human evidence actually is

Grade: FDA-approved

Approved by the FDA with randomised human trial data behind the label.

Extensive. LEADER showed reduced cardiovascular events in type 2 diabetes. SCALE established weight indications. Now largely displaced by weekly agents but its long-term record is longer than theirs.

How it is supposed to work

GLP-1 receptor agonist with an albumin-binding fatty acid chain giving a daily half-life.

Safety

Same class effects: GI intolerance, gallbladder disease, pancreatitis, rodent thyroid C-cell boxed warning.

Storage and handling

Lyophilised peptide is generally stored at 2–8 °C, or below −20 °C for long-term storage. Reconstituted in bacteriostatic water (0.9% benzyl alcohol) a solution is typically treated as usable for about 28 days refrigerated, versus roughly 24 hours for plain sterile water, which has no preservative. Add the water slowly down the vial wall and swirl — never shake, which shears peptide chains and foams the solution.

The arithmetic is the dangerous part

Whatever number a protocol or a prescriber gave you, converting it into syringe units is where a misplaced decimal becomes a tenfold error. Our calculators do that conversion and nothing else — they never invent a dose.

Open the calculators

Sources

  1. FDA prescribing information, Victoza / Saxenda
  2. LEADER trial, NEJM 2016

Verified against primary sources on 27 August 2026. Regulatory status in this field changes several times a year. See How We Rate Evidence.

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