What it is claimed to help
These are the uses attached to Matrixyl in research, clinical practice, or marketing. Listing a claim is not endorsing it — tap any of them to see every other compound carrying the same claim.
What the human evidence actually is
Small, uncontrolled, foreign-registry or single-group human studies only.
Modest but real. A double-blind, placebo-controlled split-face study reported improvement in wrinkle appearance versus vehicle. Effects are smaller than retinoids, which remain the best-evidenced topical anti-aging class.
How it is supposed to work
A procollagen I fragment (KTTKS) with a palmitoyl tail for skin penetration; signals fibroblasts to increase collagen and fibronectin production.
Safety
Well tolerated topically.
Storage and handling
Lyophilised peptide is generally stored at 2–8 °C, or below −20 °C for long-term storage. Reconstituted in bacteriostatic water (0.9% benzyl alcohol) a solution is typically treated as usable for about 28 days refrigerated, versus roughly 24 hours for plain sterile water, which has no preservative. Add the water slowly down the vial wall and swirl — never shake, which shears peptide chains and foams the solution.
Whatever number a protocol or a prescriber gave you, converting it into syringe units is where a misplaced decimal becomes a tenfold error. Our calculators do that conversion and nothing else — they never invent a dose.
Open the calculatorsSources
- Robinson LR et al. Palmitoyl pentapeptide split-face trial, Int J Cosmet Sci 2005
Verified against primary sources on 27 August 2026. Regulatory status in this field changes several times a year. See How We Rate Evidence.